If you don't contain them they are going to spread to each and every system in the network and are going to be a 10 x bigger hassle than fixing them now as is. Why use a hoe to take out what you can with a needle.
Nonetheless if you can try these.
Goto Msconfig disable everything.
Delete all the suspicious files
Go the registry keys like RUN and then remove all pointers towards the suspicious files.
As far as clearing virii I've never had a system that much infected so not sure what to do with the situation you are in.
hole.exe is what they call a Parved Worm. Maybe this link might help
http://www.symantec.com/security_res...428-99&tabid=3