KIS is the best suite on the market. However, I'd advise using MBAM or AntiSpyware as a second level of defense.
If you need more security, you'll have to go with individual components. NOD32 4.0b/KAV '09/NAV'09/Avira for AV, Comodo/Online Armor 3.1 in HIPS mode as a software firewall along with a NAT enabled router and MBAM/AntiSpyware in resident memory for spyware. For even more security, use SandboxIE.
Of course, the easiest way out is to ditch Windows altogether and embrace Linux.

Use XP in a virtual box if you need it.