Debian is ``
THE'' distro

As of right now, there are 17,000+ packaged, precompiled binaries available with latest testing release `
Etch' With these many number of packages available, you'll never need to get hold of any RPMs ever. Imagine, the entire Stable distribution of Debian `Sarge' spans 14CD sets.
In case you are going to install something on say, your laptop/home desktop where you want things to ``Just Work (TM)'' then give Ubuntu `Dapper' a try ... The only issue with Ubuntu is it needs an active internet connection to bring it to full throttle.